Nattokinase · 10,800 FU
The enzyme from natto, a fermented soy food eaten in Japan for centuries. 10,800 FU is the daily dose used in a 12-month study of 1,062 adults.
The research behind every number on our label.
Nattokinase has been studied since 1987, CoQ10 since 1957.
Here is what was studied, at what dose, and where the evidence stops.
Science
One formula, explained in full.
Four actives in two softgels a day: nattokinase, vitamin K2 as MK-7, CoQ10 and vitamin D3. We chose each dose from the published research, a cardiologist checks every claim, and you can read every study we relied on. Start with the part that matters most to you.
Our approach
We started with the research, not the price point.
In the nattokinase category, the dose usually follows the price. A formula is built to hit a number on the shelf, and the active ingredient gets whatever fits inside it.
We worked the other way round. We read the published studies first and built the formula from them with Dr. Karl Grikis, an interventional cardiologist and clinical trial investigator. He helped choose each active and its dose, and he reviews every claim we make before it reaches you.
Every ingredient is on the label, at the amount stated. No proprietary amounts. And where the research stops, we say so.
We started with the research, not the price point.
In the nattokinase category, the dose usually follows the price. A formula is built to hit a number on the shelf, and the active ingredient gets whatever fits inside it.
We worked the other way round. We read the published studies first and built the formula from them. Every ingredient is on the label, at the amount stated. No proprietary amounts.
The formula
Four actives. Every amount on the label.
Vitamin K2 MK-7 · 180 mcg
MK-7 stays in the blood far longer than vitamin K1. Supports vitamin K status and osteocalcin carboxylation.*
CoQ10 · 200 mg
As ubiquinone, a compound the body makes on its own. Supports healthy blood-vessel function* and helps reduce the everyday tiredness that builds up with age.*
Vitamin D3 · 1,000 IU
The form of vitamin D the body also makes in sunlight. Supports normal bone maintenance and normal immune function.*
What each ingredient supports.
Blood vessels
Supports healthy blood-vessel function.* CoQ10 is a compound the body makes on its own. Each serving adds 200 mg as ubiquinone.
Scientific research
Gao L. et al. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis 221, 311-316 (2012).
Everyday energy
Supports cellular energy.* CoQ10 helps your cells turn food into energy. Each serving has 200 mg.
Scientific research
Mehrabani S. et al. Effect of coenzyme Q10 supplementation on fatigue: a systematic review of interventional studies. Complementary Therapies in Medicine 43, 181-187 (2019).
Immune system
Supports normal immune function.* Each serving has 25 mcg (1,000 IU) of vitamin D3, the same form your skin makes in sunlight.
Scientific research
NIH Office of Dietary Supplements. Vitamin D: Fact Sheet for Health Professionals.
Circulation
Supports healthy circulation.* Each serving has 540 mg of nattokinase (10,800 FU, the unit for its enzyme activity). Nattokinase is an enzyme from natto, a fermented soy food eaten in Japan for centuries.
Bones
Supports bone health.* Each serving has 180 mcg of vitamin K2 as MK-7 (menaquinone-7) and 25 mcg (1,000 IU) of vitamin D3. K2 helps activate osteocalcin, a protein made in bone.
Scientific research
Schurgers L.J. et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109, 3279-3283 (2007).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The evidence
Nearly four decades of research on nattokinase.
Nattokinase was first described in 1987, in natto, a fermented soy food. It has appeared in more than 300 published papers since. These three studies matter most to us.
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Chen et al., 2022 · Frontiers in Cardiovascular Medicine
12 months, 1,062 adults, 1,001 of them at 10,800 FU a day. Not randomized, and no placebo group.
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Kurosawa et al., 2015 · Scientific Reports
One 2,000 FU dose against placebo, double-blind, in 12 healthy young men, followed for eight hours.
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Li et al., 2023 · Reviews in Cardiovascular Medicine
Six randomized trials pooled, 546 people, 2,000 to 8,000 FU a day.
The research, in detail
The studies behind the numbers on this page. For each one: how it was run, who took part, what it shows, and where it stops.
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The 12-month study behind our dose
1,062
adults, 1,001 of them at 10,800 FU
-
The largest randomized trial of nattokinase we know of
265
participants, about 3 years
-
One 2,000 FU dose, followed for eight hours
12
healthy young men
-
Six randomized trials, pooled
546
participants in 6 trials
-
How long MK-7 stays in the blood
7-8x
MK-7 accumulation with longer use.
-
CoQ10 and blood-vessel function
194
participants in 5 trials
The dose
We chose 10,800 FU because it is the daily dose in the largest nattokinase study we know of, not the amount that fits a low price. A higher dose is not proof of a larger effect, and we don't claim it is.
Our dose matches the one used in the 12-month study. That study was not run on our product.
The cardiologist behind the formula.
"My job isn't to make the product sound bigger. It's to check that the dose matches the research, the label is honest, and the people who shouldn't take it are told so clearly."
Dr. Karl Grikis, MD
Interventional cardiologist · Scientific advisor, TUDO
What Dr. Grikis reviews
- The dose of every active, against the published studies
- Every claim on the label and on this page
- The warnings: who should not take TUDO, and when to stop
Who should not take TUDO
Anyone taking warfarin or another vitamin K antagonist. Talk to your doctor first if you take blood-thinning or antiplatelet medication (including aspirin), have a bleeding disorder, are pregnant or nursing, are under 18, or have surgery planned. Stop at least 2 weeks before any procedure.
Dr. Grikis is a paid scientific advisor to TUDO.
The NIKAI™ Standard
Nattokinase, vitamin K2, CoQ10 and D3 in one daily serving, made to one published standard. NIKAI™ is that standard. It defines what goes into every softgel and how every lot is checked.
Made to
quality standard
01 / Studied form
02 / Lab tested
03 / Published COA
Why a standard, not a technology
Most supplements tell you what went into the batch. A label lists milligrams of raw material, sometimes next to a technology name that no one outside the company can check.
NIKAI™ works the other way. It isn't a patent or a secret process. It is a written specification we publish and then have to meet, lot after lot. If a lot doesn't meet it, that lot isn't sold.
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01 / Studied form
Every active is used in the form it was studied in: nattokinase from natto, vitamin K2 as MK-7, CoQ10 as ubiquinone, vitamin D3 as cholecalciferol. All four sit in an oil-filled softgel, because K2, CoQ10 and D3 are fat-soluble.
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02 / Lab tested
Potency is measured in the finished softgel, after manufacturing, by an independent ISO/IEC 17025 accredited laboratory. Not calculated from the raw material, and not taken from a supplier's certificate. The number on the label is the number the lab has to confirm, lot by lot.
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03 / Published COA
Every lot gets its own certificate of analysis: potency, identity and purity. Scan the QR code on your pouch to open this page, enter the lot number, and you see the results for the softgels in your hand.
Our shelf life is based on the manufacturer's stability data. As our own data comes in, it is added to the standard.
How it's made
Nattokinase potency is usually stated from the raw ingredient: the enzyme powder before it goes into a softgel. We test the finished softgel, every lot, and publish the result.
Enzyme activity can change during production. The raw-ingredient number tells you what went into the batch. The finished-softgel number tells you what made it into the product.
Filmed on our production line: a cGMP-certified facility, audited by SGS.
Questions about the research
Short answers to what people ask us most.
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